Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

In its latest issue, Nature Medicine published Sanaria's paper about the findings at 1 year post-PfSPZ vaccination. An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks after immunization, but the durability of protection is unknown. We assessed how vaccine dosage, regimen, and route of administration affected durable protection in malaria-naive adults.

Sanaria’s Malaria Vaccine Yields Unprecedented Protection In Clinical Trial

Results of a clinical trial of Sanaria® PfSPZ (Plasmodium falciparum sporozoite) Vaccine to prevent malaria infections, published today in the online issue of Nature Medicine magazine, show that the vaccine provided protection against infection with malaria parasites for at least 14 months in subjects who were exposed to Plasmodium falciparum parasites. The findings put the Sanaria vaccine on track to be the first malaria vaccine providing durable protection against infection with malaria parasites. Plasmodium falciparum is the malaria parasite that causes about 438,000 deaths and 214 million cases annually.

Government Of Equatorial Guinea And Oil Companies Agree To $48.5 Million Funding Of Malaria Vaccine Development Program With Sanaria Inc.

The Government of the Republic of Equatorial Guinea announced an agreement with industry partners, Marathon Oil Corporation, Noble Energy Inc. and AMPCO, to sponsor the clinical development of Sanaria® PfSPZ Vaccine against malaria, including a series of clinical trials from 2015 until 2018.

Dr. Stephen L. Hoffman wins 2015 CEO of the year at the World Vaccine Congress, Vaccine Industry Excellence Awards

Announced at the award ceremony during the 15th World Vaccine Congress, the 8th Vaccine Industry Excellence (ViE) Awards recognise those who have done outstanding work in the field, honour those who have made significant contributions to the development of the sector, and celebrate the great achievements made in the world of vaccines in the last year.

Sanaria’s Executive VP of Manufacturing and Process Development, Dr. B. Kim Lee Sim, featured in Malaymail

At a recent photoshoot by legendary photographer Annie Leibovitz of prominent scientists honoured by the Bill & Melinda Gates Foundation, one woman stood out from the rest. Dr Betty Sim Kim Lee is the president and leading researcher of an organisation working on the development of vaccines for infectious diseases. She is also a Malaysian, a proud Nyonya born and bred in Kota Bharu. So, how did this small town girl become one of the most important malaria fighters in the world today?

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres

In the latest edition of Malaria Journal, Mordmüller et al. report on their findings. Their conclusions: IV inoculation of PfSPZ is safe, well tolerated and highly reproducible. It shall further accelerate development of anti-malarial interventions through standardization and facilitation of CHMI. Beyond this, rational dose selection for whole PfSPZ-based immunization and complex study designs are now possible.

Cryoport and Sanaria Expand Logistics Partnership Supporting Malaria Vaccines distributed in Liquid Nitrogen Vapor Phase;

Cryoport, Inc., the leading provider of advanced cryogenic logistics solutions for the life sciences industry, serving markets including immunotherapies, stem cells, cell lines, clinical research organizations, vaccine manufacturers and reproductive medicine, today announced that the Company is enhancing its cryogenic logistics support of its Sanaria partnership, which includes Sanaria’s production of malaria vaccine as well as its research and development efforts.

Sanaria recognized as a NIH SBIR/STTR Notable Success

“NIH SBIR funding provided Sanaria with critical early-stage dollars to get our lead vaccine off the ground. Without this funding, Sanaria would have never gotten started and our malaria vaccine would not exist. No other investor would have provided money for this type of high-risk research.”

– Dr. Steve Hoffman, CEO of Sanaria

Read the full NIH SBIR story!|

Sanaria Inc. To Launch Crowdfunding Campaign For Sporobottm, A Mosquito-Dissecting Robot For Accelerating Manufacture Of Sanaria’s Malaria Vaccine

Biotechnology company Sanaria Inc. aims to raise at least $250,000 in 30 days on Indiegogo.com, a crowdfunding website. The campaign launches on May 6, 2014. Funds will be dedicated to the development of SporoBotTM, a robot that will dissect mosquito salivary glands. By replacing manual microdissection of mosquito salivary glands, SporobotTM will automate a key step in the manufacturing process of Sanaria® PfSPZ Vaccine against malaria.

Dr. Hoffman vs. the Mosquito

A Rockville scientist has spent 30 years struggling to eradicate malaria, the deadly insect-borne disease that has outwitted generations of medical researchers. Experts have long called his vaccine a fantasy. Now he has one last chance to prove himself.

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