Indonesian collaborators and stake holders attend meeting in Jakarta to report successful results of trial of PfSPZ vaccines in Indonesian soldiers.

Overview: In 2022-2023, Sanaria® PfSPZ Vaccine and Sanaria® PfSPZ-CVac (CQ) malaria vaccines were assessed in a phase 2 clinical trial in Papua, Indonesia, against genetically diverse, naturally transmitted Plasmodium falciparum in malaria naïve, Indonesian military personnel.  On July 17, 2024, the Faculty of Medicine, University of Indonesia (FMUI) hosted a scientific meeting in Jakarta, Indonesia attended by representatives of all the stakeholders to review the trial.

Novel vaccine, PfSPZ-LARC2 Vaccine, to prevent malaria infection developed by Seattle Children’s Research Institute and Sanaria ready for human testing

In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle Children’s Research Institute and Sanaria Inc. describe the development of a whole malaria parasite vaccine strain that infects the liver, develops to the late liver stage, and then gets completely stuck and cannot burst out of the liver to cause symptomatic blood infection.

Sanaria and Collaborators Publish Major Review of PfSPZ Vaccines

The journal Expert Review of Vaccines just published a major, open-access review of the PfSPZ Vaccines co-authored by Sanaria’s staff and 21 collaborators from 25 institutions in the US, Europe, and Africa.  The 24,000 word manuscript describes the origins, development, current status and future of Sanaria’s various vaccine platforms, emphasizing the unparalleled safety and protective efficacy of PfSPZ vaccines, innovations that have propelled progress, the critical role played by our collaborators, and the promise of PfSPZ vaccines to reduce the burden of malaria in travelers and residents of malaria-endemic areas across the world.

Trends in Parasitology Spotlights Sanaria’s In Vitro Paper Published in Nature

"The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development."

Sanaria collaborators at Seattle Children’s Research Institute report on safety and efficacy of early arresting, non-replicating, genetically attenuated malaria sporozoite vaccine.

In a publication in Science Translational Medicine, Sean Murphy, Stefan Kappe and colleagues at Seattle Children’s Research Institute (SCRI) report the safety and efficacy against controlled human malaria infection of the administration by mosquito bite of Plasmodium falciparum (Pf) parasites attenuated by deletion of three genes. 

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