Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres

In the latest edition of Malaria Journal, Mordmüller et al. report on their findings. Their conclusions: IV inoculation of PfSPZ is safe, well tolerated and highly reproducible. It shall further accelerate development of anti-malarial interventions through standardization and facilitation of CHMI. Beyond this, rational dose selection for whole PfSPZ-based immunization and complex study designs are now possible.

Peter F. Billingsley PhD, Senior Director of Entomology and Quality Systems, joins Editorial Board of the Malaria Journal

Dr. Billingsley joins a distinguished group of malariologists, in recognition of more than 20 years experience in medical entomology and malaria research. Peter has previously served on the editorial boards of major parasitology and entomology journals, the College of Experts for the Medical Research Council (UK), and advisory boards for mosquito control trials in Africa.

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